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Description
[Archie Comics vs. Marvel Comics]
They're both hot-tempered comic book powerhouses represented by the color red who possess an immense level of superhuman strength and can empower themselves by drawing energy from mystical gems (the Chaos Emeralds and Crimson Gem of Cyttorak).
Both have served as enemies, allies, and members of the heroic teams of their respective franchises (the Freedom Fighters and X-Men).
Both have also served as avatars to godly beings (Enerjak and Cyttorak) which made them take up a villainous role, but they later lost these and returned to their normal selves; although, while Knuckles did lose his role as the fourth Enerjak, Cain would eventually regain his position as Juggernaut.

Description
[Archie Comics vs. Marvel Comics]
They're both hot-tempered comic book powerhouses represented by the color red who possess an immense level of superhuman strength and can empower themselves by drawing energy from mystical gems (the Chaos Emeralds and Crimson Gem of Cyttorak).
Both have served as enemies, allies, and members of the heroic teams of their respective franchises (the Freedom Fighters and X-Men).
Both have also served as avatars to godly beings (Enerjak and Cyttorak) which made them take up a villainous role, but they later lost these and returned to their normal selves; although, while Knuckles did lose his role as the fourth Enerjak, Cain would eventually regain his position as Juggernaut.